Template imprinted materials by RFGD plasma deposition
AssigneeUniversity of Washington
InventorsBuddy D. Ratner, Huaiqiu Shi
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Abstract
Template-imprinted structures 10 are provided having at least one template-imprinted surface 12 defining indentations 14 that are capable of specifically binding cells and/or molecules, such as macromolecules including proteins, peptides and nucleic acids. Presently preferred embodiments of the template-imprinted structures include medical prostheses, such as artificial joints and heart valves, having surface indentations that specifically bind proteins and/or cells that enhance the biocompatibility of the prosthesis, thereby making it less likely that the prosthesis will be rejected by the body. Methods are also provided for making the template-imprinted structures of the present invention.
Claims12
A method for forming a template-imprinted structure comprising:
- (a) depositing a layer of sugar onto a first supporting surface bearing a plurality of templates;
- (b) forming a plasma-deposited layer by depositing plasma onto said sugar layer;
- (c) affixing said plasma-deposited layer to a second supporting surface;
- and
- (d) removing said first supporting surface and said templates.
Dependencies are inferred from the claim text.