Tricarboxylic acid-containing oxyalkyl esters and uses thereof
AssigneesBar-Ilan University, Mor Research Applications Ltd., Beacon Laboratories, Inc.
InventorsAbraham Nudelman, Ada Rephaeli
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Abstract
This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, augmenting expression of a tumor suppressor gene and inducing tolerance to an antigen. The methods of the invention use tricarboxylic acid substituted oxyalkyl esters.
Claims12
A compound represented by the formula:
- ##STR19## wherein R is n-propyl, isopropyl, 1-methylpropyl, n-butyl, isobutyl, 1-methylbutyl, 2-methylbutyl, n-amyl, isoamyl, 1-, 2-, or 3-methylamyl, 2-ethylbutyl or benzyl, any of which can be optionally substituted with halo, trifluoromethyl, amino, alkoxy or aryl;
- or R is C.sub.3 to C.sub.5 linear alkenyl, optionally substituted with halo, trifluoromethyl, amino, alkoxy or aryl;
- R.sup.1 and R.sup.2 are independently H, lower alkyl or lower alkenyl;
- A is arylene or C.sub.1 to C.sub.8 alkylene, alkenylene or alkynylene, wherein alkylene, alkenylene and alkynylene are optionally substituted with one or more of hydroxy, halo, lower alkyl, alkoxy, carbonyl, thiol, lower alkylthio or aryl;
- R.sup.3 is H, lower alkyl, aryl, or --CR.sup.1 R.sup.2 --O--C(O)--R;
- or
- a pharmaceutically-acceptable salt thereof.
Dependencies are inferred from the claim text.