Method of diagnosing Alzheimer's disease
AssigneeThe McLean Hospital Corporation
InventorRalph A. Nixon
Life of this patent
Estimating the term…
Abstract
Disclosed is a method of diagnosing Alzheimer's disease in a patient by measuring the level of a lysosomal hydrolase or lysosomal protease inhibitor in the patient's cerebrospinal fluid. The invention also features methods of measuring the progression of the disease and screening therapeutic compositions for treating Alzheimer's disease.
Claims5
A method for diagnosing probable Alzheimer's disease in a patient, said method comprising determining the level of cystatin C in cerebrospinal fluid of said patient, and comparing said level of cystatin C to normal levels, wherein an increase in cystatin C levels relative to normal indicates said diagnosis of probable Alzheimer's disease in said patient.
A method of measuring Alzheimer's disease progression in a patient, comprising determining the level of cystatin C in cerebrospinal fluid of said patient at a first time point, and determining the level of said cystatin C in cerebrospinal fluid at a second time point, wherein an increase in said cystatin C at said second time point signifies that the state of Alzheimer's disease has progressed.
Dependencies are inferred from the claim text.