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US 6,129,928 AGranted
Biomimetic calcium phosphate implant coatings and methods for making the same
AssigneeICET, Inc.
InventorsShantha Sarangapani, Paul D. Calvert
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AssigneeICET, Inc.
InventorsShantha Sarangapani, Paul D. Calvert
Estimating the term…
This invention encompasses porous, nanocrystalline, biomimetic calcium phosphate coatings of the order of 2-30 microns that can be grown on metal implants. The chemical surface treatments and methods for making the calcium phosphate coatings are disclosed. Post treatment with dilute hydrogels such as phema reinforce the inorganic structure and enhance the mechanical strength of the coatings. Methods are also disclosed for adsorbing or covalently attaching growth factor proteins to derivatives of the hydrogel coated calcium phosphate coatings. Such hydrogel reinforced calcium phosphate coatings show equivalent bone tissue growth as the currently used implants and are easily resorbed. This property in combination with the immobilized growth factors is expected to enhance the process of osseointegration of the disclosed coatings.
A method of making a biomimetic calcium phosphate coating on the surface of a metal implant comprising the sequential steps of
A method of reinforcing the strength of a calcium phosphate coated metal implant with a hydrogel polymer comprising the sequential steps of
The method of reinforcing the strength of a calcium phosphate coated metal implant with a copolymerized hydrogel comprising the sequential steps of:
A method of imbibing a growth factor into a reinforcing hydrogel polymer comprising the step of soaking a nanocrystalline calcium phosphate coated implant reinforced with a 2% (w/v) solution of the hydrogel polymer in a dilute solution of growth factor.
A kit useful for in situ coupling or absorption of growth factor proteins onto a calcium phosphate coated metal implant surface prior to implantation surgery, the kit comprising one or more containers comprising:
A method of making activated hydrogel polymers for coupling growth factor proteins, wherein the hydrogel reinforces calcium phosphate coatings on implants, comprising the steps of
Dependencies are inferred from the claim text.