Polyethylene glycol-protein compositions which reduce the antigenic display of red blood cells
AssigneeThe UAB Research Foundation
InventorsGlen L. Hortin, Shu T. Huang
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Abstract
The present invention provides a composition of matter, comprising a red blood cell coated a polymeric mixture of polyethylene glycol and albumin. Also provided is a method of blocking blood group antigens on the surface of a red blood cell, comprising the step of contacting said cell with a pharmacologically effective concentration of the composition of the present invention.
Claims19
A composition of matter, comprising a red blood cell coated with a cross-linked or branched polyethylene glycol and albumin.
A method of blocking blood group antigens on the surface of a red blood cell, comprising the step of coating said cell with a pharmacologically effective concentration of a cross-linked or branched polyethylene glycol and albumin.
A composition of matter, comprising a red blood cell coated with a cross-linked or branched polyethylene glycol and branched polyethylene glycol amine.
A composition of matter, comprising a red blood cell coated with a cross-linked or branched polyethylene glycol and a compound containing multiple reaction sites which form a cross-linked matrix with activated esters of polyethylene glycol.
A composition of matter, comprising a cell coated with a cross-linked or branched polyethylene glycol and a protein.
Dependencies are inferred from the claim text.