Nitroisourea derivative

A process for producing a nitroisourea derivative represented by formula (1):

• ##STR13## wherein R.sub.1 represents an alkyl group having from 1 to 4 carbon atoms or a benzyl group;
• R.sub.2 represents an alkyl group having from 1 to 4 carbon atoms;
• and R.sub.3 represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, said process comprising a step of reacting a nitroisourea represented by formula (2) with an amine or a salt thereof represented by formula (3) at pH of from 7.0 to 9.0:
• ##STR14## wherein R.sub.1 has the same meaning as above and wherein R.sub.2 and R.sub.3 have the same meanings as above ##STR15##

A process for producing a nitroguanidine derivative represented by formula (5):

• wherein R.sub.2 represents an alkyl group having from 1 to 4 carbon atoms;
• R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms;
• and Q represents a 5-membered or 6-membered heterocyclic ring having at least one of the following:
• a nitrogen atom, an oxygen atom or a sulfur atom, and being unsubstituted or being substituted with a halogen atom, said process comprising a step of reacting a nitroisourea derivative represented by formula (1) with an amine derivative represented by formula (4):
• ##STR16## wherein R.sub.1 represents an alkyl group having from 1 to 4 carbon atoms or a benzyl group;
• and R.sub.2 and R.sub.3 have the same meanings as above, ##STR17## wherein R.sub.4, R.sub.5, R.sub.6 and Q have the same meanings as above.