Back to results
US 6,124,449 AGranted
High affinity TGF.beta. nucleic acid ligands and inhibitors
AssigneeNeXstar Pharmaceuticals, Inc.
InventorsLarry Gold, Nikos Pagratis
Life of this patent
Estimating the term…
Abstract
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta.. Included in the invention are specific RNA ligands to TGF.beta.1 identified by the SELEX method. Also included are RNA ligands that inhibit the interaction of TGF.beta.1 with its receptor.
Claims1
A purified and isolated non-naturally occurring RNA ligand to TGF.beta.1 wherein said ligand is selected from the group consisting of the sequences set forth in Table 3 (SEQ ID NOS:
- 6-143).
Dependencies are inferred from the claim text.