Bone replacement compound comprising poly(polypropylene fumarate)
AssigneeWm. Marsh Rice University
InventorsSusan J. Peter, Michael J. Yaszemski, Antonios G. Mikos
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Abstract
A method for controlling the gel point of a bone cement containing poly(polypropylene fumarate), a cross-linking monomer, an initiator, an inorganic filler, and a radical initiator. The gel point is controlled by varying the molecular weight of the poly(polypropylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(polypropylene fumarate) above 2000 and the polydispersity index of the poly(polypropylene fumarate) below 2. In a preferred embodiment, the molecular weight of the poly(polypropylene fumarate) greater than 4000, and more preferably greater than 5000.
Claims20
A method for controlling the gel point of a biocompatible polymeric tissue scaffold containing poly(propylene fumarate), a cross-linking agent, an initiator, and an inorganic filler, comprising:
- varying the molecular weight of the poly(propylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(propylene fumarate) above 2000 and the polydispersity index of the poly(propylene fumarate) below 2.
A method for controlling the maximum temperature rise during cross-linking of a biocompatible polymeric tissue scaffold containing poly(propylene fumarate), a cross-linking agent, an initiator, and an inorganic filler, comprising:
- varying the molecular weight of the poly(propylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(propylene fumarate) above 2000 and the polydispersity index of the poly(propylene fumarate) below 2.
A method for optimizing the mechanical properties and gel time of a biocompatible polymeric tissue scaffold containing poly(propylene fumarate), a cross-linking agent monomer, an inorganic filler, and a radical initiator, comprising:
- varying the molecular weight of the poly(propylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(propylene fumarate) above 2000 and the polydispersity index of the poly(propylene fumarate) below 2.
A method for optimizing the mechanical properties and gel time of a biocompatible polymeric tissue scaffold containing poly(propylene fumarate), a cross-linking agent monomer, an inorganic filler, and a radical initiator, comprising:
- varying the molecular weight of the poly(propylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(propylene fumarate) above 2000 and the polydispersity index of the poly(propylene fumarate) below 2;
- varying the ratio of initiator to poly(propylene fumarate);
- and
- varying the ratio of monomer to poly(propylene fumarate);
- and
- varying the amount of filler in the bone cement.
Dependencies are inferred from the claim text.