Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents

The cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl compound represented by Formula III:

• ##STR50## wherein the hatched segments represent .alpha. bonds, the solid triangle represents a .beta. bond;
• the dashed bond represents a double bond or a single bond;
• R.sup.5 represents hydrogen or a lower alkyl radical having up to six carbon atoms;
• X is selected from the group consisting of --OR.sup.1 and --N(R.sup.1).sub.2 ;
• Y is .dbd.O or represents 2 hydrogen radicals;
• R.sup.1 is hydrogen or a lower alkyl radical having up to six carbon atoms;
• Z is selected from the group consisting of O and S, A is C when A is bonded directly to said alkenyl of said 2-heteroalkenyl of the and CR.sup.2 when A is not bonded directly to said alkenyl of said 2-hetero alkenyl of the compound;
• R.sup.2, R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen, halogen, cyano and lower alkyl having from 1 to 6 carbon atoms;
• wherein at least two of the radicals represented by R.sup.2, R.sup.3 and R.sup.4 are halogen, cyano, or a lower alkyl radical having from 1 to 6 carbon atoms;
• and the 9,11, or 15 alkyl esters thereof.

The cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl compound represented by Formula III:

• ##STR51## wherein the hatched segments represent .alpha. bonds, the solid triangle represents a .beta. bond;
• the dashed bond represents a double bond or a single bond;
• R.sup.5 represents hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of --OR.sup.1 and --N(R.sup.1).sub.2 ;
• Y is .dbd.O or represents 2 hydrogen radicals;
• R.sup.1 is hydrogen or a lower alkyl radical having up to six carbon atoms;
• Z is S, A is C when A is bonded directly to said alkenyl of said 2-heteroalkenyl of the and CR.sup.2 when A is not bonded directly to said alkenyl of said 2-hetero alkenyl of the compound;
• R.sup.2, R.sup.3 and R.sup.4 are selected from the group consisting of hydrogen, halogen, cyano and lower allyl having from 1 to 6 carbon atoms;
• wherein at least two of the radicals represented by R.sup.2, R.sup.3 and R.sup.4 are halogen, cyano, or a lower 1 radical having from 1 to 6 carbon atoms;
• and the 9, 11, or 15 alkyl esters thereof.