Chitin hydrogels, methods of their production and use
AssigneesChitogenics, Inc., American National Red Cross, The Coalition for Hemophilia B
InventorsWilliam N. Drohan, Martin J. MacPhee, Shirley I. Miekka, Manish S. Singh, Clive Elson, John R. Taylor, Jr.
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Abstract
This invention is directed to the preparation and utilization of supplemented chitin hydrogels, such as chitosan hydrogels. Further provided are biomaterials comprising same. The particular supplement delivered by the chitin hydrogel is selected as a function of its intended use. In one embodiment, this invention provides a composition of matter, comprising a chitin hydrogel or chitin-derived hydrogel, wherein the hydrogel does not inhibit full-thickness skin wound healing.
Claims32
A composition of matter that provides sustained release of proteins, said composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having a protein to be delivered incorporated therein in sufficient concentration to provide said sustained release.
A method of providing sustained release of proteins to a subject by administering to the subject a composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having a protein to be delivered incorporated therein in a sufficient concentration to provide said sustained release.
A method of promoting wound healing comprising administering to the wound a composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel having at least one therapeutically effective protein to be delivered incorporated therein in a sufficient concentration to provide said sustained release of said protein to said wound.
A wound dressing composition for treatment of wounded tissue, said composition comprising a covalently cross-linked N,O-carboxymethyl chitosan hydrogel;
- and a resorbable backing consisting essentially of therapeutically effective proteinaceous substances.
Dependencies are inferred from the claim text.