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US 6,123,941 AGranted
Method for restoration of normal phenotype in cancer cells
AssigneeThe Regents of the University of California
InventorsMina J. Bissell, Valerie M. Weaver
Life of this patent
Estimating the term…
Abstract
A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.
Claims9
A method for reversing malignant phenotype in tissue by administering an effective amount of an .beta..sub.1 integrin function-blocking antibody or a peptide inhibitor of integrin function to the .beta..sub.1 integrin receptors of tissue in need of such treatment.
Dependencies are inferred from the claim text.