Quenching reagents for solution phase synthesis
AssigneeWarner-Lambert Company
InventorSham Nikam
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Abstract
A method for enhancing the purity of a desired compound comprising: Step (a) treating a crude reaction product which contains at least one desired compound, unreacted starting materials and/or byproducts with at least one bifunctional quenching agent that is capable of selective covalent reaction with unwanted byproducts, or excess reagents; Step (b) allowing the quenching agent to covalently react with unreacted starting materials and/or byproducts to afford a derivatized compound of the quenching agent: and Step (c) isolating the desired compound is described as well as novel quenching agents and methods for their use in the rapid purification of synthetic intermediates and products in synthesis, combinatorial chemistry, and automated organic synthesis.
Claims10
A method for enhancing the purity of a desired compound which comprises the step of treating a crude reaction product resulting from a reaction of N-benzylamine with an excess of an electrophile, wherein the reaction product contains at least one desired compound, unreacted starting materials and/or byproducts with at least one compound of Formula I selected from the group consisting of:
- ##STR55## wherein n is an integer from 1 to 10;
- ##STR56## wherein n is an integer from 1 to 10;
- ##STR57## wherein n is an integer of from 1 to 10 and
- m is an integer from 1 to 6;
- and ##STR58## wherein n is an integer of from 1 to 10 and m is an integer from 1 to 6;
- wherein M is an alkali metal or an alkaline earth metal.
Dependencies are inferred from the claim text.