Therapeutically effective 1.alpha.,25-dihydroxyvitamin D.sub.3 analogs
AssigneeThe Regents of the University of California
InventorsAnthony W. Norman, William H. Okamura
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Abstract
Novel analogs of 1.alpha.,25-dihydroxyvitamin D.sub.3 which are selective agonists for the genomic responses or agonists or antagonists for the rapid cellular responses in a wide array of diseases in which 1.alpha.,25-dihydroxyvitamin D.sub.3 or its prodrugs are involved. Novel analogs have general formulae represented by compounds of groups I-V. A method for treatment and prevention of diseases connected with the endocrine system.
Claims38
A compound having a general formula V ##STR26## wherein the C1 and C3 hydroxyls are positional isomers .alpha. and .beta. which may be the same or different in the .alpha.--.alpha., .beta.--.beta. or .beta.-.alpha. configuration;
- wherein a C5-C6 double bond is cis or trans and a C7-C8 double bond is cis or trans;
- and
- wherein C16-C17 is a single or double bond. and wherein t R.sub.1 is a substituent selected from the group consisting of substituents ##STR27## or a pharmaceutically acceptable salt thereof.
A compound identified as analog LO, namely, 14.alpha., 15.alpha.-methano-1.alpha., 25 (OH).sub.2 D.sub.3.
The compound of claim 21 wherein the C1-C3 hydroxyls are in the .alpha.-.beta. configuration.
Dependencies are inferred from the claim text.