Electrochemical analyte measurement system

A method of determining a concentration of an analyte in a human, the method comprising steps of:

• subcutaneously implanting a plurality of non-corroding, analyte-responsive working electrode with non-leachable, analyte-responsive enzyme disposed on each of the working electrodes;
• disposing at least one counter electrode proximate to at least one of the working electrodes;
• generating a signal at each of the electrodes in response to the analyte;
• comparing the signals from at least two of the working electrodes;
• and
• accepting those signals that do not differ by more than a prescribed amount.

An electrochemical sensor, comprising:

• at least one non-corroding electrode configured and arranged for implantation in an animal;
• and
• an analyte-responsive sensing layer disposed on at least one non-corroding electrodes;
• wherein the electrochemical sensor is configured and arranged for single point, in vivo calibration of the sensor using a calibration sample from the animal.