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US 6,117,985 AGranted
Antibody compositions for preparing enriched cell preparations
AssigneeStemCell Technologies Inc.
InventorsTerry Thomas, Peter Lansdorp
Life of this patent
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Abstract
The present invention relates to antibody composition that are useful in preparing enriched cell preparations such as human hematopoietic progenitor cells and stem cells and non-hematopoietic tumor cells. The invention also relates to kits for carrying out the processes and to the cell preparations prepared by the processes.
Claims11
A negative selection process for enriching and recovering non-hematopoietic tumor cells from a sample containing non-hematopoietic tumor cells and hematopoietic cells, said process comprising
- (a) reacting the sample with an antibody composition containing antibodies capable of binding to the antigens glycophorin A, CD2, CD14, CD16, CD38, CD45 and CD66b, under conditions so that conjugates are formed between the antibodies and the hematopoietic cells in the sample containing the antigens glycophorin A, CD2, CD14, CD16, CD38, CD45 and CD66b on their surfaces;
- (b) removing the conjugates;
- and
- (c) recovering a cell preparation which is enriched in tumor cells.
1 more element
Dependencies are inferred from the claim text.