Compounds for and methods of inhibiting matrix metalloproteinases

A compound of Formula I:

• ##STR17## and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, wherein X and Y are independently O, S(O).sub.n, CH.sub.2, C.dbd.O, NH, or NC.sub.1 -C.sub.6 alkyl, provided that X and Y are not both ##STR18## n is 0, 1, or 2;
• each R.sup.1, R.sup.2, and R.sup.3 are independently halogen, hydrogen, --NO.sub.2, --NH.sub.2, --NH(C.sub.1 -C.sub.6 alkyl), --N(C.sub.1 -C.sub.6 alkyl).sub.2, --CN, --CF.sub.3, --C.sub.1 -C.sub.6 alkyl, --C.sub.1 -C.sub.6 alkoxy, --CO.sub.2 H, or --CO.sub.2 C.sub.1 -C.sub.6 alkyl;
• Q is an amino acid residue wherein the amino acid is selected from:
• D-alanine, D-valine, D-leucine, D-isoleucine, D-phenylalanine, D-proline, D-serine, D-threonine, D-tyrosine, D-asparagine, D-glutamine, D-lysine, D-arginine, D-tryptophan, D-histidine, D-cysteine, D-methionine, D-aspartic acid, D-glutamic acid, D-homophenylalanine,
• L-alanine, L-valine, L-leucine, L-isoleucine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tyrosine, L-asparagine, L-glutamine, L-lysine, L-arginine, L-tryptophan, L-histidine, L-cysteine, L-methionine, L-aspartic acid, L-glutamic acid, or L-homophenylalanine.