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AssigneeEtex Corporation
InventorsDosuk D. Lee, Christian Rey, Maria Aiolova, Aliassghar Tofighi
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The present invention provides a novel process for producing a calcium phosphate cement or filler which hardens in a temperature dependent fashion in association with an endothermic reaction. In the reaction a limited amount of water is mixed with dry calcium phosphate precursors to produce a hydrated precursor paste. Hardening of the paste occurs rapidly at body temperature an is accompanied by the conversion of one or more of the reactants to poorly crystalline apatitic calcium phosphate. The hardened cements, fillers, growth matrices, orthopedic and delivery devices of the invention are rapidly resorbable and stimulate hard tissue growth and healing.
A reactive amorphous calcium phosphate material having at least 90% percent amorphous character and characterized in that, when prepared 1:1 as a mixture with dicalcium diphosphate in water, the mixture remains injectable and formable for a time greater than about 60 minutes at about 25.degree. C. and hardens at about 37.degree. C. within about 10 to about 60 minutes.
Dependencies are inferred from the claim text.