Back to results
US 6,111,132 AGranted
Compounds and methods for synthesis and therapy
AssigneeGilead Sciences, Inc.
InventorsChoung U. Kim, Willard Lew
Life of this patent
Estimating the term…
Abstract
Novel compounds of Formula (I) are described. R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are described in this specification. Synthetic intermediates and pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Assay methods for detecting neuraminidase activity are also described.
Claims36
A compound of the formula (I):
- ##STR22## wherein:
- R.sup.1 is H, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is H;
- R is H, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is H, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;
- R.sup.1 is H, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is H;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is H;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH(CH.sub.2 CH.sub.3).sub.2 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 Ph and R.sup.3 is H;
- R.sup.1 is --CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 Ph and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.3, R.sup.2 is -(cyclohexyl) and R.sup.3 is H;
- R.sup.1 is --CH.sub.3, R.sup.2 is -(cyclohexyl) and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;
- R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;
- R.sup.1 is --CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is H;
- R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 CH.sub.2 CH.sub.3 and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 (cyclopropyl) and R.sup.3 is H;
- R.sup.1 is --CH.sub.2 CH.sub.2 CH.sub.3, R.sup.2 is --CH.sub.2 (cyclopropyl) and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is H;
- R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is H;
- R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- and R.sup.3 is H;
- or
- R.sup.1 and R.sup.2 are taken together to form --CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 -- and R.sup.3 is --CH.sub.2 CH.sub.3 ;
- and salts, solvates and resolved enantiomers thereof.
30 more elements
Dependencies are inferred from the claim text.