LTA.sub.4, hydrolase inhibitors
AssigneeG. D. Searle & Co.
InventorsBarbara Baosheng Chen, Helen Chen, Mark Andrew Russell
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Abstract
The present invention provides compounds having the structure Ar.sub.1 --Q--Ar.sub.2 --O--(CH.sub.2).sub.n --Z and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB.sub.4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.
Claims4
A compound selected from the group consisting of:
- ##STR25##
A pharmaceutical composition comprising a compound selected from the group consisting of:
- pharmaceutically acceptable salts and stereoisomers thereof, and combinations of said compounds, pharmaceutically acceptable salts and stereoisomers thereof, and a pharmaceutically acceptable carrier.
A method for treating an LTB.sub.4 -mediated inflammatory disease comprising administering to a mammal in need of treatment a therapeutically effective amount of a compound selected from the group consisting of:
- ##STR26## pharmaceutically acceptable salts and stereoisomers thereof, and combinations of said compounds, pharmaceutically acceptable salts and stereoisomers thereof.
Dependencies are inferred from the claim text.