Controlled release device based on aqueous-organic partitioning in porous membranes
AssigneeThe Trustees of the Stevens Institute of Technology
InventorsKamalesh K. Sirkar, Stephanie Farrell, Rahul Basu
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Abstract
A novel controlled release device employing microporous membranes with or without a nonporous coating and aqueous-organic partitioning of the bioreactive substances to be delivered is provided. Devices and methods for delivering pharmaceuticals, pest-control substances, hormones, nutrients and fragrances to humans, animals or any environment are also provided.
Claims10
An aqueous-organic partitioning-based, diffusion-limited reservoir-containing controlled release device comprising a microporous membrane consisting of a hollow fiber having sealed ends or a film attached to a flat-ended reservoir wherein pores extending through the microporous membrane wall are 1 nm to 10 .mu.m in size and are filled with water or an organic solvent and the fiber lumen or reservoir is filled with an organic solvent or water and a pharmaceutical so that the pharmaceutical in the fiber lumen or reservoir partitions into the water or organic solvent in the pores and diffuses through the water or organic solvent in the pores and out of the microporous membrane.
An aqueous-organic partitioning-based, diffusion-limited reservoir-containing controlled release pharmaceutical composition comprising a biodegradable or biocompatible microporous membrane comprising a hollow fiber having sealed ends or a film attached to a flat-ended reservoir and having pores extending through the microporous wall which are 1 nm to 10 .mu.m in size and are filled with water and the fiber lumen or reservoir filled with a selected drug in a non-toxic organic solvent so that the selected drug in the fiber lumen or reservoir partitions into the water in the pores and diffuses through the water in the pores and out of the microporous membrane.
An aqueous-organic partitioning-based, diffusion-limited reservoir-containing controlled release pharmaceutical composition comprising a biodegradable or biocompatible microporous membrane comprising a hollow fiber having sealed ends or a film attached to a flat-ended reservoir and having pores extending through the microporous membrane wall which are 1 nm to 10 .mu.m in size and are filled with a non-toxic organic solvent and the fiber lumen or reservoir filled with a selected drug in water so that the selected drug in the fiber lumen or reservoir partitions into the non-toxic organic solvent in the pores and diffuses through the non-toxic organic solvent in the pores and out of the microporous membrane.
Dependencies are inferred from the claim text.