Vaccine for swine infertility and respiratory syndrome and method of use thereof
AssigneesRegents of the University of Minnesota, South Dakota State University, Boechringer Ingelheim Vetmedica, Inc.
InventorsJames E. Collins, David A. Benfield, Danny W. Chladek, Louis L. Harris, David E. Gorcyca
Life of this patent
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Abstract
The invention includes a vaccine and sera for treatment of Mystery Swine Disease (MSD), a method for producing the vaccine, methods for diagnosis of MSD, a viral agent that will mimic "mystery swine disease" and antibodies to the viral agent useful in diagnosis and treatment of MSD. The serum contains mammalian antibodies which are effective in treating MSD.
Claims19
A vaccine comprising attenuated swine infertility and respiratory syndrome virus, wherein said attenuated swine infertility and respiratory syndrome virus is produced by a process comprising passaging a swine infertility and respiratory syndrome virus through simian cells to form an attenuated swine infertility and respiratory syndrome virus which is non-zoopathogenic in swine;
- and
- the swine infertility and respiratory syndrome virus is a fastidious, non-hemagglutinating, enveloped RNA virus.
A vaccine suitable for use in prevention of swine infertility and respiratory syndrome, comprising:
- (a) attenuated swine infertility and respiratory syndrome virus;
- and
- (b) pharmaceutical carrier;
- wherein the attenuated swine infertility and respiratory syndrome virus produced by a process comprising passaging swine infertility and respiratory syndrome virus ATCC VR-2332 through simian cells to form modified swine infertility and respiratory syndrome virus which is non-zoopathogenic in swine.
A vaccine comprising attenuated swine infertility and respiratory syndrome virus, wherein said attenuated swine infertility and respiratory syndrome virus is produced by a process comprising:
- homogenizing tissue from swine affected with swine infertility and respiratory syndrome to form a homogenate which includes swine infertility and respiratory syndrome virus, wherein the swine infertility and respiratory syndrome virus is a fastidious, non-hemagglutinating, enveloped RNA virus;
- and
- passaging the swine infertility and respiratory syndrome virus through simian cells to form an attenuated swine infertility and respiratory syndrome virus which is non-zoopathogenic in swine, wherein the passaging step comprises incubating simian cells inoculated with material from the homogenate.
Dependencies are inferred from the claim text.