Reovirus for the treatment of neoplasia
AssigneeOncolytics Biotech Inc.
InventorsPatrick W. K. Lee, James Strong, Matthew C. Coffey
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Abstract
Methods for treating neoplasia, by administering reovirus to a Ras-mediated neoplasm, are disclosed. The reovirus is administered so that it ultimately directly contacts cells of the neoplasm. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, type 1 (e.g., strain Lang), type 2 (e.g., strain Jones), type 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
Claims39
A method of treating a Ras-mediated neoplasm in a mammal suffering from said neoplasm, wherein said method comprises administering to the neoplasm an effective amount of a naturally-occurring reovirus under conditions which result in reovirus-mediated oncolysis of the cells of the Ras-mediated neoplasm.
A method of treating a Ras-mediated neoplasm in a human suffering from said neoplasm, wherein said method comprises administering to the neoplasm an effective amount of a naturally-occurring reovirus under conditions which result in reovirus-mediated oncolysis of the cells of the Ras-mediated neoplasm.
A method of treating a Ras-mediated neoplasm in a mammal suffering from said neoplasm, wherein said method comprises administering directly to the neoplasm an effective amount of a naturally-occurring reovirus under conditions which result in reovirus-mediated oncolysis of cells of the Ras-mediated neoplasm.
A method of treating a Ras-mediated neoplasm in a human suffering from said neoplasm, wherein said method comprises administering directly to the neoplasm an effective amount of a naturally-occurring reovirus under conditions which result in reovirus-mediated oncolysis of cells of the Ras-mediated neoplasm.
A method of treating a Ras-mediated neoplasm in a mammal suffering from said neoplasm, wherein said method comprises administering directly to the neoplasm multiple doses of an effective amount of a naturally-occurring reovirus under conditions which result in reovirus-mediated oncolysis of cells of the Ras-mediated neoplasm.
A method of treating a Ras-mediated neoplasm in a human suffering from said neoplasm, wherein said method comprises administering directly to the neoplasm multiple doses of an effective amount of a naturally-occurring reovirus under conditions which result in reovirus-mediated oncolysis of cells of the Ras-mediated neoplasm.
Dependencies are inferred from the claim text.