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US 6,110,209 AGranted
Method and paste for articular cartilage transplantation
OwnerKevin R. Stoneinventor
Life of this patent
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Abstract
The invention disclosed is a method and material for repairing focal arthritic defects in a mammalian joint, especially in a human knee. The invention disclosed provides an articular cartilage cancellous bone paste in an effective amount for enhancing formation of cartilage. The paste can include a cartilage-stimulating factor.
Claims7
An articular cartilage paste comprising:
- an osteocartilaginous tissue mixture for effecting in vivo cartilage formation, the osteocartilaiinous tissue mixture comprising crushed articular cartilage and cancellous bone,
- a cartilage-stimulating factor,
- wherein the cartilage-stimulating factor comprises a TGF-.beta. growth factor in an amount ranging from about 0.1 ug/ml to about 1.0 ug/ml.
An articular cartilage paste comprising:
- an osteocartilaginous tissue mixture for effecting in vivo cartilage formation, the osteocartilaginous tissue mixture comprising crushed articular cartilage and cancellous bone,
- a cartilage-stimulating factor,
- wherein the cartilage-stimulating factor is contained within a non-toxic, bioabsorbable carrier.
An articular cartilage paste comprising:
- an osteocartilaginous tissue mixture for effecting in vivo cartilage formation, the osteocartilaginous tissue mixture comprising crushed articular cartilage and cancellous bone, further comprising:
- a plurality of cells.
An articular cartilage paste comprising:
- an osteocartilaginous tissue mixture for effecting in vivo cartilage formation, the osteocartilaginous tissue mixture comprising crushed articular cartilage and cancellous bone, further comprising:
- a biological glue.
Dependencies are inferred from the claim text.