Green porphyrins as immunomodulators
AssigneesQLT PhotoTherapeutics, Inc., The University of British Columbia
InventorsAgnes H. Chan, David W. C. Hunt, Julia G. Levy, Modestus O. K. Obochi, Anna M. Richter, Guillermo O. Simkin
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Abstract
Green porphyrins act as antigen-specific immunomodulators in the active phase of an immune response to a particular antigen. This effect occurs at ambient light levels.
Claims17
A method to modulate an antigen-specific immune response which method comprises administering to a subject in need of such modulation, an amount of green porphyrin effective to modulate said immune response to the antigen, said administering being performed during the ongoing antigen-specific immune response to said antigen, and maintaining said subject in ambient light for a sufficient time to effect immunomodulation, but maintaining viability of the cells of said subject,
- wherein said ambient light is less than one-quarter the total energy of light required to induce erythema in said subject after administering said effective amount of green porphyrin.
Dependencies are inferred from the claim text.