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US 6,107,062 AGranted
Antisense viruses and antisense-ribozyme viruses
AssigneeInpax, Inc.
InventorsWen Hu, Jie Wang
Life of this patent
Estimating the term…
Abstract
Antisense viruses and antisense ribozyme viruses are disclosed. The novel artificial viruses, their synthesis and their use in preventing and treating viral infections are presented.
Claims11
An HIV antisense virus comprising:
- a viral coat the same as the viral coat of an HIV virus, and
- nucleic acid including an antisense fragment which is antisense to a section of a gene encoding a transactivating protein required for said HIV virus to replicate, said antisense fragment encoding antisense RNA which binds and inactivates mRNA encoded by said gene encoding a transactivating protein.
An antisense proviral molecular clone including
- structural genes of an HIV virus, and
- an antisense fragment which is antisense to a section of a gene encoding a transactivating protein required for said HIV virus to replicate, said antisense fragment encoding antisense RNA and mRNA encoded by said gene encoding a transactivating protein.
A method of synthesizing an antisense proviral molecular clone comprising the steps of:
- a) inserting DNA encoding an HIV virus into a vector;
- and
- b) creating an antisense fragment in said DNA by turning antisense a section of a gene of said DNA, said gene encoding a transactivating protein required for said HIV virus to replicate, said antisense fragment encoding antisense RNA mRNA encoded by said gene encoding a transactivating protein.
Dependencies are inferred from the claim text.