Immunomodulatory peptides of vespid antigen 5
AssigneeThe Rockfeller University
InventorTe Piao King
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Abstract
The present invention is directed to immunogenic peptides from vespid antigen 5. These immunogenic peptides can be used in immunotherapy for vespid venom allergic individuals. The present invention is thus directed to T cell epitopes of vespid antigen 5 that can anergize T cell responses in sensitive individuals.
Claims11
A method for treating sensitivity to vespid venom antigen 5 comprising administering to a vespid venom allergic patient a therapeutically effective amount of a peptide characterized by the following properties:
- a) it has a range of about 8 to about 35 amino acid residues of vespid venom antigen 5;
- and,
- b) it is antigenic for T cell proliferation in a mouse immunized with a vespid venom antigen 5, which mouse is a strain selected from the group consisting of BALB/c, ASW/Sn, C3H/He, and P/J.
A method for treating sensitivity to vespid venom antigen 5 comprising administering to a vespid venom allergic patient a therapeutically effective amount of a peptide having an amino acid sequence selected from the group consisting of:
- a) NNYCKIKCRKGIHTLCKFGT (SEQ ID NO:8), or its homolog;
- b) GIHTLCKFGTSMKPNCGRNV (SEQ ID NO:9), or its homolog;
- c) NNYCKIKCRKGIHTLCKFGTGTSMKPNCGRNV (SEQ ID NO:42), or its homolog;
- d) KNEILKRHNDFRQNVAKGLE (SEQ ID NO:
- 12), or its homolog;
- e) FRQNVAKGLETRGKPGPQPP (SEQ ID NO:
- 13), or its homolog;
- f) KNEILKRHNDFRQNVAKGLETRGKPGPQPP (SEQ ID NO:43), or its homolog;
- g) DELAKIAQTWANQCDFNHDD (SEQ ID NO:16), or its homolog;
- h) NYKVGLQNSNFRKVGHYTQM (SEQ ID NO:22), or its homolog;
- i) FRKVGHYTQMVWGKT (SEQ ID NO.23), or its homolog;
- j) NYKVGLQNSNFRKVGHYTQMVWGKT (SEQ ID NO:44), or its homolog;
- k) IEDNWYTHYLVCNYGPGGND (SEQ ID NO:26), or its homolog.
A method for treating sensitivity to vespid venom antigen 5 comprising administering to a vespid venom allergic patient a therapeutically effective amount of a recombinant polypeptide comprising two or more peptides non-contiguously arranged relative to the native sequence of vespid venom antigen 5, wherein the peptides are selected from the group consisting of:
- a) NNYCKIKRKGIHTLCKFGT (SEQ ID NO:8), or its homolog;
- b) GIHTLCKFGTSMKPNCGRNV (SEQ ID NO:9), or its homolog;
- c) NNYCKIKCRKGIHTLCKFGTGTSMKPNCGRNV (SEQ ID NO:42), or its homolog;
- d) KNEILKRHNDFRQNVAKGLE (SEQ ID NO:12), or its homolog;
- e) FRQNVAKGLETRGKPGPQPP (SEQ ID NO:13), or its homolog;
- f) KNEILKRHNDFRQNVAKGLETRGKPGPQPP (SEQ ID NO:43), or its homolog;
- g) DELAKIAQTWANQCDFNHDD (SEQ ID NO:16), or its homolog;
- h) NYKVGLQNSNFRKVGHYTQM (SEQ ID NO:22), or its homolog;
- i) FRKVGHYTQMVWGKT (SEQ ID NO:23), or its homolog;
- i) NYKVGLQNSNFRKVGHYTQMVWGKT (SEQ ID NO:44), or its homolog;
- and,
- k) IEDNWYTHYLVCNYGPGGND (SEQ ID NO:26), or its homolog.
Dependencies are inferred from the claim text.