Water-wettable chromatographic media for solid phase extraction
AssigneeWaters Corporation
InventorsEdouard S. P. Bouvier, Randy E. Meirowitz, Patrick D. McDonald
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Abstract
A method for removing an organic solute from a solution, comprising contacting the solution with a polymer formed by copolymerizing one or more hydrophobic monomers and one or more hydrophilic monomers, whereby the solute is adsorbed onto the polymer. The solution can comprise a polar solvent such as a polar organic solvent or water or an aqueous buffer. The hydrophobic monomer can be, for example, divinylbenzene. The hydrophilic monomer can be, for example, a heterocyclic monomer, such as a vinylpyridine or N-vinylpyrrolidone.
Claims8
A method for producing a solution comprising a first solvent and a solute, wherein the concentration of said solute in said solution is greater than the concentration of the solute in a starting solution comprising a second solvent and the solute, the method comprising the steps of:
- (a) contacting a volume of the starting solution with a water-wettable polymer formed by copolymerizing at least one hydrophobic monomer and at least one hydrophilic monomer, said polymer comprising from about 12 mole percent to about 30 mole percent of the hydrophilic monomer, whereby the solute is adsorbed onto the polymer;
- and
- (b) washing the polymer with a volume of the first solvent, said volume of the first solvent being less than the volume of the starting solution in step (a), thereby desorbing the solute from the polymer and forming a solution of the solute in the first solvent wherein the concentration of the solute in said solution is greater than the concentration of the solute in the starting solution.
Dependencies are inferred from the claim text.