Antisense inhibition of PI3K p85 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Lex M. Cowsert
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of PI3K p85. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PI3K p85. Methods of using these compounds for modulation of PI3K p85 expression and for treatment of diseases associated with expression of PI3K p85 are provided.
Claims21
An antisense compound 8 to 30 nucleobases in length targeted to nucleobases 88-3314 of the coding region of human pI3K p85 (SEQ ID NO:
- 1), wherein said antisense compound specifically hybridizes with and inhibits the expression of human pI3K p85.
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 21, 22, 27, 28, 30, 33, 40, 41, 8, 9, 12, 13, 14, 15, 17, 18, 20, 23, 24, 32, 37, 42 or 43 which inhibits the expression of human pI3K p85.
Dependencies are inferred from the claim text.