Wettable silicone-based lenses
AssigneeJohnson & Johnson Vision Products, Inc.
InventorJames J. Jen
Life of this patent
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Abstract
This invention provide silicone-based, biomedical devices that exhibit improved wettability as well as biocompatability through the use of functional silane agents. More specifically, the invention provides devices at least one surface of which has a functional silane coupling agent and hydrophilic polymer.
Claims29
A device comprising a biomedical device at least one surface of the device having a reactive effective amount of one or more functional silane coupling agents and a coating effective amount of one or more hydrophilic polymers.
A device comprising a contact lens at least one surface of the lens having a reactive effective amount of one or more functional silane coupling agents of the formula X.sub.3 (Si)CH.sub.2).sub.n Y wherein n is 0 to 3, X is Cl, CH.sub.3 O- or C.sub.2 H.sub.5 O- and Y is an organofunctional group selected from the group consisting of acrylic, amino, chloro, epoxy, glycidoxy, mercapto, methacryloxy, and vinyl and a coating effective amount of one or more hydrophilic polymers.
A device comprising a contact lens at least one surface of the lens having a reactive effective amount of one or more functional silane coupling agents selected from the group consisting of vinyl benzyl cationic silane, vinyl-tris(.beta.-methoxyethoxy)silane, vinyltriacetoxysilane, .gamma.-methacryloxypropyltrimethoxysilane, .gamma.-aminopropyltriethoxysilane, .gamma.-(.beta.-aminoethyl) aminopropyl trimethoxysilane, .gamma.-glycidoxypropyltrimethoxysilane, .gamma.-mercaptopropyltrimethoxysilane, .beta.-(3,4-epoxycyclohexyl)-ethyltrimethoxysilane, .gamma.-chloropropyltrimethoxysilane, and mixtures thereof, and a coating effective amount of one or more hydrophilic polymers selected from the group consisting of hydroxyethyl (meth)acrylate, (meth)acrylamide, N,N-dimethylacrylamide, N-vinylpyrrolidone, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, polyacrylic acid, polyethyleneoxide bisacetic acid, and mixtures thereof.
A method for manufacturing biomedical devices comprising the steps of contacting at least one surface of a silicone-polymer based biomedical device with a reactive effective amount of one or more functional silane coupling agents and subsequently coating the contacted surface with a coating effective amount of one or more hydrophilic polymers.
Dependencies are inferred from the claim text.