Hepatocyte growth factor receptor agonists and uses thereof
AssigneeGenentech, Inc.
InventorsKenneth J. Hillan, Ralph H. Schwall, Kelly H. Tabor
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Abstract
Hepatocyte growth factor (HGF) receptor agonists are provided. The HGF receptor agonists include HGF receptor antibodies and fragments thereof. The HGF receptor agonists can be employed to substantially enhance HGF receptor activation. The HGF receptor agonists may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treatment and diagnosis using the HGF receptor agonists are also provided.
Claims29
The monoclonal antibody produced by the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC HB-12093.
A composition comprising a monoclonal antibody produced by the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC HB-12093 and a carrier.
The hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC HB-12093.
A hepatocyte growth factor (HGF) receptor agonist antibody which binds to a HGF receptor, wherein the antibody binds to the same epitope as the epitope to which the monoclonal antibody produced by the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC HB-12093 binds.
A method of treating a pathological liver condition in a mammal, comprising administering a heptaocyte growth effective amount of a monoclonal antibody produced by the hybridoma cell line deposited under American Type Culture Collection Accession Number ATCC HB-12093 to the mammal.
Dependencies are inferred from the claim text.