Composition and method for treating inflammatory diseases
AssigneeAmgen Inc.
InventorsDavid S. Collins, Michael P. Bevilacqua
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Abstract
A pharmaceutical composition comprising (a) an effective amount of controlled release polymer and (b) an effective amount of a proteinaceous IL-1 inhibitor. The composition exhibits a therapeutic effect on inflammation and is useful for treating IL-1 mediated inflammatory diseases, particularly diseases of the joint.
Claims20
A pharmaceutical composition comprising synergistic amounts of a hyaluronan or a salt thereof, and an interleukin-1 (IL-1) receptor antagonist (IL-1ra), wherein said IL-1ra comprises all or an IL-1 inhibitory fragment of an amino acid having a sequence of SEQ ID NO:2, or a sequence which is at least about 70% homologous to said amino acid sequence.
Dependencies are inferred from the claim text.