High pressure MS/MS system
AssigneeMDS Inc.
InventorsGholamreza Javahery, Bruce Thomson, Charles Jolliffe
Life of this patent
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Abstract
A mass spectrometer system in which ions are mass selected in an RF-only quadrupole at relatively high pressure (1 to 7 torr) using FNF or SWIFT, and are then fragmented in a following collision cell which is in the same vacuum chamber, thus reducing pumping needs. The fragments can be mass analyzed in any desired way, including by another RF-only quadrupole in the same vacuum chamber and also using FNF or SWIFT. Triple MS can be performed in the same way.
Claims9
A method of mass spectrometry comprising mass selecting ions in a first multipole rod set operated at a pressure of at least approximately 1 millitorr, by applying an auxiliary field to said first rod set to excite and thereby remove all ions therefrom except for parent ions, and then transmitting the parent ions into a second multipole rod set operated at substantially the same pressure as the first multipole rod set, and fragmenting parent ions in said second multipole rod set.
A method of mass spectrometry comprising providing ions from an ion source, mass selecting said ions from said ion source to provide first parent ions, fragmenting said first parent ions to provide first daughter ions, mass selecting said first daughter ions to isolate said first daughter ions, fragmenting said first daughter ions to provide second daughter ions, and transmitting said second daughter ions into a mass spectrometer for mass separation thereof, for detection;
- the steps of fragmenting said first parent ions, selecting said first daughter ions, and fragmenting said first daughter ions being carried out in at least two multipole rod sets in a chamber at one pressure, said pressure being at least approximately one millitorr, thereby to provide MS/MS/MS.
Dependencies are inferred from the claim text.