N-acyl sulfamic acid esters useful as hypocholesterolemic agents

A compound of formula ##STR4## or a pharmaceutically acceptable salt thereof wherein:

• R.sup.1 is hydrogen, alkyl, or alkoxy;
• R.sup.2 to R.sup.5 are alkyl, alkoxy, or unsubstituted or substituted phenyl;
• R.sup.6 is --CN,
• --(CH.sub.2).sub.0-1 --NR.sup.7 R.sup.8,
• --O--(CH.sub.2).sub.1-10 --Z wherein Z is --NR.sup.9 R.sup.10, OR.sup.1, or CO.sub.2 R.sup.1,
• --OC(.dbd.O)R.sup.11,
• --SR.sup.11,
• --SCN,
• --S(CH.sub.2).sub.1-10 Z,
• --S(O).sub.1-2 R.sup.12 wherein R.sup.12 is hydroxy, alkoxy, alkyl, (CH.sub.2).sub.1-10 Z or NR.sup.7 R.sup.8,
• --C(.dbd.O)XR.sup.11,
• --CH.sub.2 --R.sup.13 wherein R.sup.13 is (CH.sub.2).sub.0-5 --Y--(CH.sub.2).sub.0-5 Z, or
• wherein R.sup.7 and R.sup.8 are each independently selected from:
• --hydrogen, at least one of R.sup.7 and R.sup.8 is other than hydrogen,
• --(CH.sub.2).sub.1-10 Z wherein Z is as above and R.sup.9 and R.sup.10 are each independently selected from hydrogen, alkyl, and unsubstituted or substituted phenyl, or
• R.sup.9 and R.sup.10 are taken together with the nitrogen to which they are attached to form a ring selected from:
• --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2,
• --(CH.sub.2).sub.2 --S--(CH.sub.2).sub.2,
• --(CH.sub.2).sub.2 --CR.sup.14 R.sup.15 --(CH.sub.2).sub.1-2, and
• --(CH.sub.2).sub.2 --NR.sup.16 --(CH.sub.2).sub.2, wherein
• R.sup.14, R.sup.15, and R.sup.16 are each independently selected from hydrogen, alkyl, and unsubstituted or substituted phenyl;
• --C(.dbd.Q)XR.sup.11 wherein X is a bond or NH wherein Q is O or S,
• R.sup.11 is hydrogen, alkyl, unsubstituted or substituted phenyl,
• --(CH.sub.2).sub.0-5 --Y--(CH.sub.2).sub.0-5 Z wherein Z is as defined above and Y is phenyl or a bond;
• --C(.dbd.O)CR.sup.17 R.sup.18 Z;
• --C(.dbd.O)NRCR.sup.17 R.sup.18 Z wherein R.sup.17 and R.sup.18 are each independently hydogen, alkyl, phenyl, substituted phenyl, or the side chain of a naturally occurring amino acid;
• --S(O).sub.1-2 R.sup.19 wherein R.sup.19 is alkyl, unsubstituted or substituted phenyl, naphthyl, or a heteroaromatic ring, or NR.sup.9 R.sup.10 or
• R.sup.7 and R.sup.8 are taken together with the nitrogen to which they are attached to form a ring:
• --(CH.sub.2).sub.2 --O--(CH.sub.2).sub.2 --,
• --(CH.sub.2).sub.2 --S--(CH.sub.2).sub.2 --,
• --(CH.sub.2).sub.2 --CR.sup.14 R.sup.15 --(CH.sub.2).sub.1-2 --,
• --(CH.sub.2).sub.2 --NR.sup.16 --(CH.sub.2).sub.2 -- wherein R.sup.14, R.sup.15, and R.sup.16 are as above.