Frangible compounds for pathogen inactivation
AssigneeCerus Corporation
InventorsDavid Cook, John E. Merritt, Aileen Nerio, Henry Rapoport, Adonis Stassinopoulos, Susan Wollowitz, Jan Matejovic
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Abstract
Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.
Claims46
A compound selected from the group consisting of:
- ##STR18## and all salts thereof.
A compound having the formula:
- ##STR19## and all salts thereof.
A compound having the formula:
- ##STR20## and all salts thereof.
A compound having the formula:
- ##STR21## and all salts thereof.
A compound having the formula:
- ##STR22## and all salts thereof.
A compound having the formula:
- ##STR23## and all salts thereof.
A compound having the formula:
- ##STR24## and all salts thereof.
A compound having the formula ##STR25## and all salts thereof.
Dependencies are inferred from the claim text.