Combined dehydroepiandrosterone and retinoid therapy for epithelial disorders
AssigneeBioResponse, L.L.C.
InventorMichael A. Zeligs
Life of this patent
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Abstract
The present invention relates to compositions and methods for the treatment of oxidative epithelial damage, for inadequate surfactant production in lung disorders, and for disorders of the urinary bladder epithelium. The compositions of the present invention comprise dehydroepiandrosterone and vitamin A derivatives.
Claims57
A composition for the treatment of epithelial damage in a mammal comprising a pharmacologically active retinoid and pharmacologically active DHEA wherein the combination is effective in preventing or reversing damage to the epithelium due to environmental oxidative agents and wherein the proportion of retinoid and DHEA is sufficient to overcome the undesirable side effects of each composition when used alone.
A method for treating epithelial damage in a mammal comprising administering a pharmacologically active retinoid in an amount sufficient to counteract undesirable side effects of administered DHEA and a pharmacologically active DHEA in an amount sufficient to counteract undesirable side effects of administered retinoid to the mammal wherein the combination is effective in preventing or reversing damage to the epithelium due to environmental oxidative agents.
A composition for the treatment of inadequate surfactant production in the lungs of a mammal comprising a pharmacologically active retinoid and a pharmacologically active DHEA.
A method for treating inadequate surfactant production in the lungs of a mammal comprising administering a pharmacologically active retinoid and pharmacologically active DHEA.
A method for counteracting the toxicity of retinoid administration comprising administering a pharmacologically active DHEA to a patient to whom a retinoid is administered as a mode of treatment, wherein the DHEA is administered in an amount sufficient to counteract the toxic effects of the administered retinoid.
Dependencies are inferred from the claim text.