Modified HGP-30 peptides, conjugates, compositions and methods of use
AssigneeCel-Sci Corporation
InventorsDaniel H. Zimmerman, Prem S. Sarin
Life of this patent
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Abstract
An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS or at risk for AIDS. The peptide has from about 25 to about 37 amino acids, such as, for example, the sequence ##EQU1##
Claims18
A peptide having the formula of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4 OR SEQ ID NO:5 or a natural or spontaneous occurring allele thereof.
A peptide-carrier construct comprising the formula (I):
- C*--X--P* (I)
- wherein
- C* represents an immunogenic carrier material;
- P* represents a peptide having SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4 or SEQ ID NO:5;
- and
- X represents a direct bond or covalent linkage linking the immunogenic carrier material C* and the peptide P*.
A peptide having SEQ ID NO:2.
A peptide having SEQ ID NO:3.
A peptide having SEQ ID NO:4.
A peptide having SEQ ID NO:5.
Dependencies are inferred from the claim text.