Meniscal heterografts
AssigneeCrossCart, Inc.
InventorKevin R. Stone
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Abstract
The invention provides an article of manufacture comprising a substantially non-immunogenic knee meniscal heterografts for implantation into humans. The invention further provides a method for preparing a knee meniscal heterograft by removing at least a portion of a meniscus from a non-human animal to provide a heterograft; washing the heterograft in saline and alcohol; subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, freeze/thaw cycling, and optionally to chemical crosslinking. In accordance with the invention the heterograft has substantially the same mechanical properties as the native xenogeneic meniscus.
Claims14
An article of manufacture comprising a substantially non-immunogenic meniscal heterograft for implantation into a human, produced by the process of
- a. removing at least a portion of a medial or lateral meniscus from a knee joint of a non-human animal to provide a heterograft;
- b. washing the heterograft in water and alcohol;
- c. subjecting the heterograft to at least one treatment selected from the group consisting of exposure to ultraviolet radiation, immersion in alcohol, ozonation, and freeze/thaw cycling;
- and
- d. treating the heterograft with a glycosidase to remove surface carbohydrate moieties, whereby the heterograft has substantially the same mechanical properties as a corresponding portion of a native medial or lateral meniscus.
A meniscal heterograft for implantation into a human comprising
- a portion of a medial or lateral meniscus from a knee joint of a non-human animal, wherein the portion has substantially no surface carbohydrate moieties which are susceptible to glycosidase digestion, and
- whereby the portion is substantially non-immunogenic and has substantially the same mechanical properties as a corresponding portion of a native medial or lateral meniscus.
Dependencies are inferred from the claim text.