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AssigneeUniversity of Florida
InventorsEugene P. Goldberg, James F. Kirk, Lynn S. Peck
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An improved method for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The polymeric material is (1) a substantially water-soluble polymer having at least one C.sub.n F.sub.2n+1 substituent wherein n.gtoreq.4, having a molecular weight of less than about 60,000; (2) a pharmaceutically acceptable salt or complex thereof; or (3) mixtures thereof. The concentration of the aqueous solution of the polymeric material is in the range of from about 0.1% to about 5.0% by weight, the molecular weight and concentration having values such that the aqueous solution is capable of providing wet coatings on the tissue.
A method of preventing post-operative surgical adhesions of tissue and protecting tissue and preventing tissue damage in surgery comprising providing said tissue surfaces involved in said surgery with a wet coating of a physiologically acceptable aqueous solution of a hydrophilic, polymeric material prior to manipulation of said tissue during said surgery, wherein:
A surgical article having surfaces adapted for contacting tissue surfaces during surgery, said surfaces of said surgical article having a wet coating thereon, said wet coating comprising a physiologically acceptable aqueous solution of a hydrophilic, polymeric material wherein:
A method of protecting from damage tissues or organs during harvesting thereof from animals or humans, manufacture therefrom of bioprostheses and subsequent manipulations and implantations of said bioprostheses in animals or humans, comprising providing said tissue or organ surfaces with a wet coating of a physiologically acceptable aqueous solution of a hydrophilic, polymeric material prior to and during said harvesting, manufacture of bioprostheses, manipulations and implantations thereof, wherein:
A bioprosthesis comprised at least in part of tissue or an organ or part thereof of an animal or human, said tissue or organ or part thereof having a coating thereon of a physiologically acceptable aqueous solution of a hydrophilic, polymeric material to protect said tissue or organ or part thereof from damage arising during harvesting thereof from said animal or human, manufacture of said bioprosthesis and manipulations and implantations of said bioprosthesis in animals or humans, wherein:
A method of protecting from damage tissues or organs or parts thereof during harvesting thereof from animals or humans, subsequent manipulations and implantations of said tissues or organs or parts thereof in animals or humans, comprising providing said tissue and organ surfaces with a wet coating of a physiologically acceptable aqueous solution of a hydrophilic, polymeric material prior to and during said harvesting, manipulations and implantations thereof, wherein:
Dependencies are inferred from the claim text.