Surface modifying composition and method
AssigneeSurModics, Inc.
InventorsCary Reich, Jeffrey Forsberg, Harold Levy, Jean Toner-Webb
Life of this patent
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Abstract
Synthetic surfaces such as surfaces of implantable prosthetic devices are modified to enhance their ability to support the growth, migration and attachment of epithelial cells. A surface modifier composition is covalently bound to the synthetic surface, and an epithelial cell-supporting coating is applied to the modified surface. The surface modifier composition may also include an epithelial cell-supporting material. The invention is particularly suited towards the modification of synthetic epikeratophakia lenses.
Claims15
A method for modifying a synthetic surface, the method comprising the steps of:
- a) applying to the synthetic surface a surface modifying composition comprising (i) polymer molecules having pendant functional groups capable of being converted by photolysis to highly reactive groups, and (ii) molecules of another material lacking pendant functional groups capable of being converted by photolysis to highly reactive groups,
- b) photolysing the composition in order to convert the functional groups to highly reactive groups and thereby simultaneously covalently bind the polymer molecules by reaction of the highly reactive groups with the other material and the synthetic surface, wherein the surface is the surface of a device selected from the group consisting of a prosthetic device to be implanted into the body, a tissue culture plate, and a device for supporting in vitro epithelial cell growth.
A modified synthetic surface formed by a process that comprises the steps of a) providing a synthetic surface, b) applying to the synthetic surface a surface modifying composition comprising (i) polymer molecules having pendant functional groups capable of being converted by photolysis to highly reactive groups, and (ii) molecules of another material lacking pendant functional groups capable of being converted by photolysis to highly reactive groups, and c) photolysing the composition in order to convert the functional groups to highly reactive groups and thereby simultaneously covalently bind the polymer molecules by reaction of the highly reactive groups with the other material and the synthetic surface, wherein the surface is the surface of a device selected from the group consisting of the surface of a prosthetic device to be implanted into the body, the surface of a tissue culture plate, and the surface of a device for supporting in vitro epithelial cell growth.
Dependencies are inferred from the claim text.