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AssigneeEpic Therapeutics, Inc.
InventorsJames E. Woiszwillo, Larry R. Brown, Terrence L. Scott, Jie Di, Judith Sudhalter, Charles D. Blizzard
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Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
A method of making microparticles comprising combining a macromolecule and a polymer in an aqueous solution at a pH near the isoelectric point of the macromolecule and exposing the solution to an energy source for a sufficient amount of time to form microparticles.
A method of making microparticles comprising combining a macromolecule and a polymer in an aqueous solution at a pH near the isoelectric point of the macromolecule, exposing the solution to an energy source for a sufficient amount of time to form microparticles, and adding a pharmaceutical compound.
A microparticle prepared by a method comprising combining a macromolecule with a polymer in an aqueous solution at a pH near the isoelectric point of the macromolecule and exposing the solution to an energy source for a sufficient amount of time to form the microparticle.
A microparticle prepared by a method comprising combining a macromolecule with a polymer in an aqueous solution at a pH near the isoelectric point of the macromolecule, exposing the solution to an energy source for a sufficient amount of time to form the microparticle, and adding a pharmaceutical compound.
A method for delivering a therapeutic agent to a patient comprising administering to the patient a therapeurically effective amount of a microparticle comprising a macromolecule and a polymer in an aqueous solution, wherein the concentration of the macromolecule in the microparticle is at least 40% and less than 100% by weight, wherein the macromolecule comprises a therapeutic agent.
A method for delivering a therapeutic agent to a patient comprising administering to the patient a therapeutically effective amount of a microparticle comprising a macromolecule and a polymer in an aqueous solution, wherein the concentration of the macromolecule in the microparticle is at least 40% and less than 100% by weight, and wherein the microparticle further comprises luteinizing hormone releasing hormone (LHRH) or an analog thereof, wherein the analog has LHRH agonist or antagonist activity, and wherein the LHRH or LHRH analog is the therapeutic agent.
A method for forming a microparticle comprising:
A microparticle comprising:
A microparticle comprising:
Dependencies are inferred from the claim text.