Triclosan skin wash with enhanced efficacy
AssigneeSTERIS Inc.
InventorsNancy E. Kaiser, Denise K. Pretzer
Life of this patent
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Abstract
A disinfectant hand wash includes Triclosan and a reduced amount of surfactants in order to reduce skin irritation while maintaining improved activity against Gram negative and Gram positive organisms, including Serratia marcescens. The hand wash includes an effective amount of Triclosan, preferably 0.2-3.0% and a non-aqueous solvent. Hexylene glycol, or a mixture of hexylene glycol and isopropanol as the non-aqueous solvent provide improved efficacy in killing skin-born microbes. The hand wash further includes less than about 10% surfactant, preferably less than 5%. The hand wash further includes a chelating agent, a thickener, a buffering agent, and water.
Claims22
A skin wash composition comprising:
- (a) about 0.2 to about 3.0% Triclosan;
- (b) about 1.0 to about 30.0% of a non-aqueous solvent which includes hexylene glycol;
- (c) less than about 10.0% surfactant;
- (d) about 0.0 to about 1.0% chelating agent;
- (e) a thickener present in a sufficient amount to provide a viscosity of at least 500 cps;
- (f) about 0.0 to about 5.0% buffering agent;
- and
- (g) water.
A method of disinfecting skin comprising:
- (a) applying to the skin an effective amount of a composition including:
- about 0.2 to about 3.0% Triclosan;
- about 1.0 to about 30.0% of a non-aqueous solvent which includes hexylene glycol;
- less than about 10.0% surfactant;
- about 0.0 to about 1.0% chelating agent;
- a thickener present in a sufficient amount to provide a viscosity of at least 500 cps;
- about 0.0 to about 5.0% buffering agent;
- and water;
- and,
- b) maintaining contact between the composition and the skin for sufficient time to kill substantially all microorganisms present on the surface.
A skin wash composition comprising:
- (a) about 0.2 to about 3.0% Triclosan;
- (b) about 1.0 to about 30.0% of a non-aqueous solvent which includes:
- a glycol, and
- a lower alcohol selected from the group consisting of isopropanol, ethanol, and n-propanol;
- (c) less than about 8.0% surfactant;
- (d) about 0.0 to about 1.0% chelating agent;
- (e) a thickener present in a sufficient amount to provide a viscosity of at least 500 cps;
- (f) about 0.0 to about 5.0% buffering agent;
- and
- (g) water.
A skin wash composition comprising:
- (a) 0.2-1.5% Triclosan;
- (b) 2.0-8.0% surfactant;
- (c) 4-15% hexylene glycol;
- (d) 3-10% lower alcohol;
- (e) a buffer which buffers pH to 4.5-6.0;
- and
- (f) a thickener which adjusts viscosity to 500-2500 cps.
Dependencies are inferred from the claim text.