Antisense oligonucleotide modulation of human thymidylate synthase expression
AssigneeIsis Pharmaceuticals, Inc.
InventorNicholas M. Dean
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Abstract
Compounds, compositions and methods are provided for modulating the expression of human thymidylate synthase. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding thymidylate synthase. Methods of using these oligonucleotides for modulation of thymidylate synthase expression and for treatment of diseases such as cancers believed to be responsive to modulation of thymidylate synthase expression are provided.
Claims10
An antisense oligonucleotide 8 to 30 nucleotides in length comprising a nucleotide sequence complementary to a nucleic acid molecule encoding human thymidylate synthase, wherein said oligonucleotide is complementary to the 3' untranslated region of said nucleic acid molecule and inhibits the expression of said human thymidylate synthase.
An antisense oligonucleotide 8 to 30 nucleotides in length comprising a nucleotide sequence complementary to a nucleic acid molecule encoding human thymidylate synthase, wherein said oligonucleotide is complementary to the 3' untranslated region of said nucleic acid molecule and which inhibits cell proliferation.
Dependencies are inferred from the claim text.