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AssigneesNitroMed, Inc., The Brigham and Women's Hospital, Inc.
InventorsJonathan S. Stamler, Joseph Loscalzo, John D. Folts
Estimating the term…
A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; can be coated per se on a surface of the medical device; can be directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.
A method for preventing adverse effects associated with the use of a medical device in a patient comprising introducing into said patient a medical device of which at least a portion includes a nitric oxide adduct, wherein said nitric oxide adduct comprises a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite or a nitrosated amino acid.
A method for preventing adverse effects associated with the use of a medical device in a patient comprising introducing into said patient a medical device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue, wherein said nitric oxide adduct comprises a sodium nitroprusside, a nitrosothiol, a nitrite or a nitrosylated amino acid.
A medical device comprising an instrument suitable for introduction into a patient of which at least a portion comprises a nitric oxide adduct, wherein said nitric oxide adduct comprises a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite or a nitrosated amino acid.
Dependencies are inferred from the claim text.