Disubstituted bicyclic heterocycles, the preparations and the use thereof as pharmaceutical compositions

A compound of the formula I

• R.sub.a --A--Het--B--Ar--E (I)
• wherein
• A denotes a carbonyl or sulphonyl group linked to the benzo moiety of the group Het,
• B denotes an ethylene group, wherein a methylene group, linked either to the group Het or Ar, is optionally replaced by an oxygen or sulphur atom or by a sulphinyl, sulphonyl, carbonyl or --NR.sub.1 group, wherein
• R.sub.1 denotes a hydrogen atom or a C.sub.1-6 -alkyl group,
• E denotes a cyano or R.sub.b NH--C(.dbd.NH)-- group wherein
• R.sub.b denotes a hydrogen atom, a hydroxy group, C.sub.1-9 -alkoxycarbonyl, cyclohexyloxycarbonyl, phenyl-C.sub.1-3 -alkoxycarbonyl, benzoyl, p-C.sub.1-3 -alkyl-benzoyl or pyridinoyl group, whilst the ethoxy moiety in the 2-position of the abovementioned C.sub.1-9 -alkoxycarbonyl group is optionally, additionally, substituted by a C.sub.1-3 -alkylsulfonyl or 2-(C.sub.1-3 -alkoxy)-ethyl group,
• Ar denotes a phenylene or naphthylene group optionally substituted by a fluorine, chlorine or bromine atom or by a trifluoromethyl, C.sub.1-3 -alkyl or C.sub.1-3 -alkoxy group, or a thienylene group optionally substituted in the carbon skeleton by a C.sub.1-3 -alkyl group,
• Het denotes a bicyclic heterocycle of formula ##STR9## wherein, X is a nitrogen atom and
• Y is an imino group optionally substituted by a C.sub.1-6 -alkyl or C.sub.3-7 -cycloalkyl group
• and R.sub.a denotes an R.sub.2 NR.sub.3 -- group wherein
• R.sub.2 denotes a C.sub.1-4 -alkyl group, which is optionally substituted by a carboxy, C.sub.1-6 -alkyloxycarbonyl, benzyloxycarbonyl, C.sub.1-3 -alkylsulphonylaminocarbonyl, phenylsulphonylaminocarbonyl, trifluorosulphonylamino, trifluorosulphonylaminocarbonyl or 1H-tetrazolyl group, or
• a C.sub.2-4 -alkyl group substituted, at a carbon which is other the one in the .alpha.-position relative to the adjacent nitrogen atom, by a hydroxy, phenyl-C.sub.1-3 -alkoxy, carboxy-C.sub.1-3 -alkylamino, C.sub.1-3 -alkoxycarbonyl-C.sub.1-3 -alkylamino, N-(C.sub.1-3 -alkyl)-carboxy-C.sub.1-3 -alkylamino or N-(C.sub.1-3 -alkyl)-C.sub.1-3 -alkoxycarbonyl-C.sub.1-3 -alkylamino group, and
• R.sub.3 denotes a pyridinyl group optionally substituted by a methyl group,
• or, if E is a group of the formula R.sub.b NH--C--(.dbd.NH)--, a physiologically acceptable salt thereof or, if E is a cyano group, a salt thereof.