Methods and compositions for the inhibition of interleukin-12 production
AssigneesThe Wistar Insitute, The Johns Hopkins University
InventorsChristopher L. Karp, Giorgio Trinchieri, Maria Wysocka, Diane E. Griffin
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Abstract
The invention includes compositions and methods for selective suppression of IL-12 production in a cell. Methods of treating a human having a disease associated with dysregulated IL-12 production are also provided.
Claims12
A method of suppressing IL-12 production in a human in need of such suppression, said method comprising administering to said human a ligand that binds the complement receptor protein CD46, wherein said ligand is suspended in a pharmaceutically acceptable carrier and said binding suppresses IL-12 production.
A method of suppressing IL-12 production in a cell, said method comprising administering to said cell a ligand that binds the complement receptor protein CD46, wherein said binding suppresses IL-12 production.
Dependencies are inferred from the claim text.