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US 6,086,875 AGranted
Receptor specific transepithelial transport of immunogens
AssigneesThe Brigham and Women's Hospital, Inc., Brandeis University
InventorsRichard S. Blumberg, Neil E. Simister, Wayne L. Lencer
Life of this patent
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Abstract
Methods and products for modulating an immune response are provided. Pharmaceutical preparations contain a conjugate of an antigen and a FcRn binding partner. The conjugates are administered to mammals in effective amounts to modulate the immune system by stimulating the immune response against the antigen or tolerizing the immune system to the antigen. The antigen may be characteristic of a pathogen, of an autoimmune disease or of an allergen.
Claims12
A method for activating or suppressing a systemic immune response in a mammal comprising:
- administering to the luminal side of an epithelial barrier of an epithelial tissue expressing FcRn receptor an effective amount of a conjugate of an FcRn binding partner and an antigen selected from group consisting of:
- an antigen characteristic of a pathogen,
- an antigen characteristic of an autoimmune disease, and
- an antigen characteristic of an allergen.
1 more element
Dependencies are inferred from the claim text.