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US 6,086,740 AGranted
Multiplexed microfluidic devices and systems
AssigneeCaliper Technologies Corp.
InventorColin B. Kennedy
Life of this patent
Estimating the term…
Abstract
Multiplexed microfluidic devices include a plurality of modular microfluidic elements, all of which are attached to a common frame or substrate, which itself includes one or more common input elements that are connected to corresponding input elements within several or each of the microfluidic modules for use in common control and/or common detection operations for each of the modules.
Claims31
A multiplexed microfluidic device, comprising:
- a plurality of microfluidic modules, each module comprising a discrete channel network disposed therein;
- at least a first substrate having at least a first fluidic element disposed therein;
- wherein the plurality of microfluidic modules are attached to the first substrate such that the at least first fluidic element is in separate fluid communication with a fluidic element disposed within each of the microfluidic modules.
A multiplexed microfluidic device, comprising:
- a plurality of microfluidic modules each module having a microfluidic channel network disposed therein, each microfluidic channel network comprising at least first and second miroscale channels;
- and
- a common frame attached to each of the plurality of modules, the frame including a common input element, the input element being operably coupled simultaneously to the microfluidic channel networks in each of the plurality of microfluidic modules.
A microfluidic system, comprising:
- a multiplexed microfluidic device that comprises a plurality of microfluidic modules attached to a first substrate, wherein a fluidic element in the first substrate is in fluid communication with at least one of a first and second intersecting microscale channels disposed within each of the plurality of microfluidic modules;
- a material transport system operably coupled to each of the first fluidic element and the first and second microscale channels, for transporting material from the first fluidic element into and through the at least one of the first and second microscale channels;
- a detector disposed in sensory communication with at least one of the first and second channels in the microfluidic modules, for detecting a signal within the at least one channel.
A method of manufacturing a multiplexed microfluidic device, comprising:
- providing a substrate having at least a first fluidic element disposed therein, and a plurality of openings disposed from a surface of the substrate to the fluidic element;
- and
- attaching a plurality of microfluidic modules to the substrate, each microfluidic module comprising at least first fluidic element disposed therein and an opening providing access from a surface of the microfluidic module to the first fluidic element in the microfluidic module, wherein the fluidic element in each of the microfluidic modules comprises at least first and second intersecting microfluidic channels, the modules being attached to the substrate such that each of the plurality openings on the substrate is in fluid communication with an opening on a separate microfluidic module.
Dependencies are inferred from the claim text.