Chimpanzee adenovirus vectors
AssigneeThe Trustees of the University of Pennsylvania
InventorsJames M. Wilson, Steven F. Farina, Krishna J. Fisher
Life of this patent
Estimating the term…
Abstract
A recombinant vector comprises chimpanzee adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses chimpanzee adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
Claims30
A non-simian mammalian cell that expresses a chimpanzee adenovirus gene obtained from the sequence of SEQ ID NO:
- 1.
A nucleic acid molecule comprising a chimpanzee adenovirus DNA sequence comprising a gene obtained from the sequence of SEQ ID NO:
- 1.
A vector comprising a chimpanzee adenovirus DNA sequence obtained from SEQ ID NO:
- 1 and a selected heterologous gene operatively linked to regulatory sequences which direct expression of said gene in a heterologous host cell wherein said chimpanzee adenovirus DNA sequence comprises at least the cis-elements necessary for replication and virion encapsidation, said cis-elements flanking said selected heterologous gene and regulatory sequences.
A non-simian mammalian cell that expresses a chimpanzee adenovirus gene obtained from the sequence of SEQ ID NO:
- 2.
A nucleic acid molecule comprising a chimpanzee adenovirus DNA sequence comprising a gene obtained from the sequence of SEQ ID NO:
- 2.
A vector comprising a chimpanzee adenovirus DNA sequence obtained from SEQ ID NO:
- 2 and a selected heterologous gene operatively linked to regulatory sequences which direct expression of said gene in a heterologous host cell wherein said chimpanzee adenovirus DNA sequence comprises at least the cis-elements necessary for replication and virion encapsidation, said cis-elements flanking said selected heterologous gene and regulatory sequences.
Dependencies are inferred from the claim text.