Drug salts
AssigneeDumex-Alpharma A/S
InventorsHjarne Dyrsting, Torben Koch
Life of this patent
Estimating the term…
Abstract
It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide poly-O-sulphonic acid salts of antibiotics such as tetracyclins and aminoglycosides.
Claims19
A therapeutic compound which is a substantially water-insoluble salt of a mono to octa-saccharide sugar acid having oxyacid groups with a biologically active organic compound selected from the group consisting of aminoglycosides, tetracylines, polypeptides, glycopeptides and macrolides.
A therapeutic compound which is a substantially water-insoluble salt of a mono to octa-saccharide sugar acid having oxyacid groups with a biologically active organic compound selected from the group consisting of aminoglycosides, tetracyclines, polypeptides, glycopeptides and macrolides, and a physiologically tolerable counterion.
A pharmaceutical composition comprising a biologically active organic compound in the form of a salt with a sugar acid having oxyacid groups together with at least one physiologically acceptable carrier or excipient, said salt being a substantially water-insoluble salt of a mono to octa-saccharide sugar acid with a biologically active organic compound selected from the group consisting of aminoglycosides, tetracylines, polypeptides, glycopeptides and macrolides.
A method of antibacterial treatment of a warm-blooded animal with an antibacterially effective amount of a biologically active organic compound selected from the group consisting of aminoglycosides, tetracylines, polypeptides, glycopeptides and macrolides to combat a condition responsive to said compound, said method comprising administering to said warm-blooded animal said effective amount of said organic compound in the form of a substantially water-insoluble salt with a mono to octa-saccharide sugar acid having oxyacid groups.
Dependencies are inferred from the claim text.