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AssigneeSurModics, Inc.
InventorsDale G. Swan, Richard A. Amos, Terrence P. Everson
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A chemical linking agent is formed of a di- or higher functional photoactivatable compound having at least one group that is charged to improve water solubility, and two or more photoreactive groups (preferably comprising an aryl ketone such as benzophenone) that allow use of the agent in aqueous systems. Charged groups include salts of organic acids such as sulfonate, phosphonate and carboxylate groups, onium groups such as quaternary ammonium, sulfonium and phosphonium groups, and protonated amines. A surface can be coated with a substance such as a synthetic polymer, carbohydrate, protein, lipid, nucleic acid, drug, vitamin, cofactor or dye by forming an aqueous solution of the linking agent and the substance, placing the solution in contact with the surface and activating the photoreactive groups of the linking agent to cross-link the substance to the surface.
A photoactivatable chemical linking agent capable, upon activation, of covalent attachment to a surface and/or target molecule, the agent comprising a charged, nonpolymeric di- or higher functional photoactivatable compound comprising two or more photoreactive groups, each capable of being activated to form a covalent bond with the surface or target molecule, and one or more charged groups, wherein the number and/or type of charged group(s) is sufficient to provide the agent with sufficient aqueous solubility to allow the agent to be used in a solvent system having water as the major component and wherein each charged group is independently selected from the group consisting of sulfonate, phosphonate, and carboxylate groups, wherein the photoreactive groups each, independently, comprise an aryl ketone.
A photoactivatable cross-linking agent comprising a compound of the formula:
A photoactivatable cross-linking agent comprising:
A surface bearing a coating comprising a target molecule cross-linked to the surface by the activation of a photoactivatable chemical linking agent, the agent comprising a charged, nonpolymeric di- or higher functional photoactivatable compound, the compound comprising two or more photoreactive groups activated to form covalent bonds with the surface and the target molecule and one or more charged groups, wherein the number and/or type of charged group(s) is sufficient to provide the agent with sufficient aqueous solubility to allow the agent to be used in a solvent system having water as the major component, wherein the photoreactive groups each, independently, comprise an aryl ketone, and wherein the charged groups are each independently selected from the group consisting of sulfonate, phosphonate, and carboxylate groups.
A method of coating a surface with a target molecule, the method comprising the steps of:
Dependencies are inferred from the claim text.